Hydrochloric Acid → N-(2-t-Butyloxycarbonylaminoethyl)-N-(thymin-1-yl-amino-carbonyl)glycine

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Reaction Steps

The product from Example 6, 9, is dissolved in ethanol (500 mL) and 2M sodium hydroxide (50 mL) is added. The reaction is stirred for 6 hours, then neutralized with 50 mL of 2M HCl solution, and evaporated to remove the ethanol. The residue is dissolved in dichloromethane (250 mL) and is extracted with water (2×50 mL), dried, filtered, and evaporated to a solid.

Provenance & Evidence