Hydrochloric Acid → N-(2-t-Butyloxycarbonylaminoethyl)-N-(thymin-1-yl-amino-carbonyl)glycine

HRID 1735945Notes

Reaction equation

HRID 1735945 reaction equation
C([O:3][C:4](=[O:29])[CH2:5][N:6]([CH2:19][CH2:20][NH:21][C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[C:7]([NH:9][N:10]1[CH:18]=[C:16]([CH3:17])[C:14](=[O:15])[NH:13][C:11]1=[O:12])=[O:8])C.[OH-].[Na+].Cl>C(O)C>[C:25]([O:24][C:22]([NH:21][CH2:20][CH2:19][N:6]([C:7]([NH:9][N:10]1[CH:18]=[C:16]([CH3:17])[C:14](=[O:15])[NH:13][C:11]1=[O:12])=[O:8])[CH2:5][C:4]([OH:29])=[O:3])=[O:23])([CH3:28])([CH3:26])[CH3:27]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 19076261HCID 19076261, compound

Product 1

HCID 19076263N-(2-t-Butyloxycarbonylaminoethyl)-N-(thymin-1-yl-amino-carbonyl)glycine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The product from Example 6, 9, is dissolved in ethanol (500 mL) and 2M sodium hydroxide (50 mL) is added. The reaction is stirred for 6 hours, then neutralized with 50 mL of 2M HCl solution, and evaporated to remove the ethanol. The residue is dissolved in dichloromethane (250 mL) and is extracted with water (2×50 mL), dried, filtered, and evaporated to a solid.

Workup

  1. customevaporated
  2. customto remove the ethanol
  3. dissolutionThe residue is dissolved in dichloromethane (250 mL)
  4. extractionis extracted with water (2×50 mL)
  5. customdried
  6. filtrationfiltered
  7. customevaporated to a solid

Sources & evidence

ORD record
ord-a633c6db1e004fcb9bb8762ebd7c2996
Source dataset
uspto-grants-1996_07
Patent number
US05539082

Reaction notes

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