HCID 19434127, compound → HCID 54017237, compound

HRID 1735996Notes

Reaction equation

HRID 1735996 reaction equation
[CH2:1]([O:3][CH2:4][CH2:5][CH2:6][N:7]1[CH2:12][CH:11]([OH:13])[C:10]2[CH:14]=[C:15](S(N)(=O)=O)[S:16][C:9]=2[S:8]1(=O)=O)[CH3:2].CC(C)(C)C([O-])([O-])[O-]>C(#N)C>[CH2:1]([O:3][CH2:4][CH2:5][CH2:6][N:7]1[CH2:12][CH:11]([OH:13])[C:10]2[CH:14]=[CH:15][S:16][C:9]=2[S:8]1)[CH3:2]

Participants

4

Reactant 2

HCID 19434127HCID 19434127, compoundHCID 21927715Trimethylorthoacetate

Product 1

HCID 54017237HCID 54017237, compoundYield 167.8%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The product from Step D (1.6 g, 4.32 mmol) was dissolved in dry acetonitrile (20 mL) and trimethylorthoacetate (11 mL) was added. The mixture was heated at reflux temperature for 18 hr and then evaporated to provide an oil (1.88 g, 100%) which was used without further purification.

Workup

  1. temperatureThe mixture was heated
  2. temperatureat reflux temperature for 18 hr
  3. customevaporated

Sources & evidence

ORD record
ord-fb6c10520bc24f9bae103a4c7e4e5a10
Source dataset
uspto-grants-1996_07
Patent number
US05538966

Reaction notes

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