Hydrochloric Acid → HCID 19434929, compound

HRID 1736101Notes

Reaction equation

HRID 1736101 reaction equation
C([N:4]([C:19]1[CH:24]=[CH:23][C:22]([C:25]2[O:26][C:27]3[CH:35]=[CH:34][C:33]([F:36])=[C:32]([NH2:37])[C:28]=3[C:29](=[O:31])[CH:30]=2)=[CH:21][CH:20]=1)[CH2:5][CH2:6][CH2:7][N:8]1[C:12](=[O:13])[C:11]2=[CH:14][CH:15]=[CH:16][CH:17]=[C:10]2[C:9]1=[O:18])(=O)C.Cl.[OH-].[Na+].O>O1CCOCC1>[NH2:37][C:32]1[C:28]2[C:29](=[O:31])[CH:30]=[C:25]([C:22]3[CH:21]=[CH:20][C:19]([NH:4][CH2:5][CH2:6][CH2:7][N:8]4[C:12](=[O:13])[C:11]5=[CH:14][CH:15]=[CH:16][CH:17]=[C:10]5[C:9]4=[O:18])=[CH:24][CH:23]=3)[O:26][C:27]=2[CH:35]=[CH:34][C:33]=1[F:36]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 15346989HCID 15346989, compound

Product 1

HCID 19434929HCID 19434929, compoundYield 87%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

6.0 g of Compound 14 was dissolved in 90 ml of dioxane, 60 ml of concentrated hydrochloric acid was added and the mixture was heated at reflux for 5 hours. The reaction solution was cooled on ice and adjusted to pH 7.5 by addition of a 10N aqueous solution of sodium hydroxide thereto, water was further added, and the precipitated crystals were collected by filtration to give 4.78 g (87%) of Compound 15.

Workup

  1. temperaturethe mixture was heated
  2. temperatureat reflux for 5 hours
  3. temperatureThe reaction solution was cooled on ice
  4. filtrationthe precipitated crystals were collected by filtration

Sources & evidence

ORD record
ord-6624338d0b624eeca7dda74f3e48c105
Source dataset
uspto-grants-1996_07
Patent number
US05539112

Reaction notes

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