反应详情

3.90 g of Compound 25 was dissolved in 180 ml of dioxane, 180 ml of concentrated hydrochloric acid was added and the mixture was heated at reflux for 3 hours. The reaction solution was cooled on ice, and the precipitated crystals were collected by filtration and recrystallized from methanol/chloroform to give 1.31 g (52%) of Compound 26.

1. temperaturethe mixture was heated
2. temperatureat reflux for 3 hours
3. temperatureThe reaction solution was cooled on ice
4. filtrationthe precipitated crystals were collected by filtration
5. customrecrystallized from methanol/chloroform