反应详情

1.0 g of Compound 28 was dissolved in 12 ml of dioxane, 8 ml of concentrated hydrochloric acid was added and the mixture was heated at reflux for 4.3 hours. The reaction solution was cooled on ice and adjusted to pH 8 by addition of a 10N aqueous solution of sodium hydroxide thereto, and the precipitated crystals were collected by filtration to give 805 mg (87%) of Compound 29.

1. temperaturethe mixture was heated
2. temperatureat reflux for 4.3 hours
3. temperatureThe reaction solution was cooled on ice
4. filtrationthe precipitated crystals were collected by filtration