反应详情

温度

50 °C

30 ml ethanol and 4.3 ml of a 2N aqueous solution of sodium hydroxide were added to 560 mg (1.43 mmol) of Compound 44 obtained in Example 44 and the mixture was stirred at 50° C. for 10 minutes. The reaction solution was cooled to room temperature and the precipitated crystals were collected by filtration to give 533 mg (97%) of Compound 45.

1. temperatureThe reaction solution was cooled to room temperature
2. filtrationthe precipitated crystals were collected by filtration