Sodium Hydroxide → 5-amino-2-(4-carboxymethylamino-3-fluorophenyl)-6,8-difluoro-4H-1-benzopyran-4-one

Participants

Reaction Conditions

Reaction Steps

30 ml ethanol and 4.3 ml of a 2N aqueous solution of sodium hydroxide were added to 560 mg (1.43 mmol) of Compound 44 obtained in Example 44 and the mixture was stirred at 50° C. for 10 minutes. The reaction solution was cooled to room temperature and the precipitated crystals were collected by filtration to give 533 mg (97%) of Compound 45.

Provenance & Evidence