HCID 19434937, compound → HCID 19434837, compound

HRID 1736202Notes

Reaction equation

HRID 1736202 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([F:36])[C:5]2[O:10][C:9]([C:11]3[CH:16]=[CH:15][C:14]([NH:17]C(=O)C(C)(C)C)=[C:13]([F:24])[CH:12]=3)=[CH:8][C:7](=[O:25])[C:6]=2[C:26]=1[NH:27][CH2:28][CH2:29][CH2:30][N:31]1[CH:35]=[CH:34][N:33]=[CH:32]1>S(=O)(=O)(O)O>[NH2:17][C:14]1[CH:15]=[CH:16][C:11]([C:9]2[O:10][C:5]3[C:4]([F:36])=[CH:3][C:2]([F:1])=[C:26]([NH:27][CH2:28][CH2:29][CH2:30][N:31]4[CH:35]=[CH:34][N:33]=[CH:32]4)[C:6]=3[C:7](=[O:25])[CH:8]=2)=[CH:12][C:13]=1[F:24]

Participants

3

Reactant 1

HCID 19434937HCID 19434937, compound

Product 1

HCID 19434837HCID 19434837, compoundYield 68%

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

Substantially the same manner as that in Example 127 (4) was repeated except that 600 mg (1.21 mmol) of the above 6,8-difluoro-2-(3-fluoro-4-pivaloylaminophenyl)-5-[3-(imidazol-1-yl)propylamino]-4H-1-benzopyran-4-one was used, treatment with 20 mL of concentrated sulfuric acid was carried out and the resulting compound was recrystallized from methanol, to give 341 mg of Compound 129 (yield: 68%).

Workup

  1. customthe resulting compound was recrystallized from methanol

Sources & evidence

ORD record
ord-1cfb2df132834f01b1bf968d7843f171
Source dataset
uspto-grants-1996_07
Patent number
US05539112

Reaction notes

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