Styrene → Styrene Oxide

HRID 1736267Notes

Reaction equation

HRID 1736267 reaction equation
C=CC1C=CC=CC=1.[C:9]([OH:24])(=O)[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]CCCCCC>>[CH2:9]1[O:24][CH:10]1[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Participants

3

Reactant 2

HCID 7501StyreneHCID 11005Myristic Acid

Product 1

HCID 7276Styrene OxideYield 16.5%

Procedure

To a stirred suspension (at room temperature) of immobilized C. antarctica lipase (370 mg, according to example 1) in styrene (4.15 ml, 36.1 mmol) containing myristic acid (823 mg, 3.6 mmol) hydrogen peroxide (3 ml, 52.5 mmol) was added in six equal portions after 0, 0.5, 1.0, 1.5, 2.0 and 3.0 hours. After 1.5 hours 16.5% styrene oxide was formed as determined by gas chromatography.

Workup

  1. customTo a stirred suspension (at room temperature) of immobilized C
  2. additionwas added in six equal portions after 0, 0.5, 1.0, 1.5, 2.0 and 3.0 hours

Sources & evidence

ORD record
ord-68a00f77e4804ce8aabde1eeac1bf91e
Source dataset
uspto-grants-1996_07
Patent number
US05541092

Reaction notes

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