反应详情

N-(4-Bromo-2-cyano-5-fluoro-6-hydroxy-3-methylphenyl)-2,2-dimethyl-3-[(phenylmethyl)oxy]propionamide (I-105) (5.82 g, 13.37 mmol) was dissolved in ethyl acetate (120 ml), carbon-held palladium catalyst (5% wet, 580 mg) was added, followed by vigorously stirring at room temperature under atmospheric pressure of hydrogen for 18 hours. After the reaction, the insoluble matter was separated by filtration through Celite, the filtrate was concentrated under reduced pressure. The resulting residue was recrystallized and purified with n-hexane/ethyl acetate to obtain the entitled compound (2.32 g, 50%) as a white solid.

1. additioncarbon-held palladium catalyst (5% wet, 580 mg) was added
2. customAfter the reaction
3. customthe insoluble matter was separated by filtration through Celite
4. concentrationthe filtrate was concentrated under reduced pressure
5. customThe resulting residue was recrystallized
6. custompurified with n-hexane/ethyl acetate