反应详情

105.5 Milliliters of 2,2-diethoxyethylamine was dropwise added to 138 g of 4-bromo-2-methylphenyl isothiocyanate with ice-cooling. The mixture was stirred for 10 minutes and then further stirred for 10 minutes at 100° C. The mixture was allowed to cool, and thereto was added 500 ml of 8 N hydrochloric acid. The mixture was refluxed for 2 hours. The resulting crystals were collected by filtration, washed with water thoroughly and then dried to obtain 110 g of 1-(4-bromo-2-methylphenyl)-2-mercaptoimidazole.

1. temperaturecooling
2. stirringfurther stirred for 10 minutes at 100° C
3. temperatureto cool
4. temperatureThe mixture was refluxed for 2 hours
5. filtrationThe resulting crystals were collected by filtration
6. washwashed with water thoroughly
7. customdried