Methanol → N-(4,7-dimethyl-5-benzimidazolyl)-N'-2-aminoethylthiourea

HRID 1736464Notes

Reaction equation

HRID 1736464 reaction equation
[CH3:1][C:2]1[C:10]2[NH:9][CH:8]=[N:7][C:6]=2[C:5]([CH3:11])=[CH:4][C:3]=1[N:12]=[C:13]=[S:14].CO.[CH2:17]([NH2:20])[CH2:18][NH2:19]>C(Cl)Cl>[CH3:1][C:2]1[C:10]2[NH:9][CH:8]=[N:7][C:6]=2[C:5]([CH3:11])=[CH:4][C:3]=1[NH:12][C:13]([NH:19][CH2:18][CH2:17][NH2:20])=[S:14]

Participants

5

Reactant 3

HCID 887MethanolHCID 3301EthylenediamineHCID 214727244,7-Dimethyl-5-benzimidazolylisothiocyanate

Product 1

HCID 21472717N-(4,7-dimethyl-5-benzimidazolyl)-N'-2-aminoethylthiourea

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A solution of 4,7-dimethyl-5-benzimidazolylisothiocyanate (0.59 g) in CH2Cl2 (50 mL)/methanol (5 mL) is added dropwise over 20 minutes to ethylenediamine (1 mL) in solution in CH2Cl2 (150 mL). The mixture is stirred for 2 hours at room temperature. The resulting suspension is filtered and the solid is dried overnight in vacuo to afford N-(4,7-dimethyl-5-benzimidazolyl)-N'-2-aminoethylthiourea as a white solid.

Workup

  1. filtrationThe resulting suspension is filtered
  2. customthe solid is dried overnight in vacuo

Sources & evidence

ORD record
ord-3c8348cbcc1f4a1f813f5bc8b5cd5245
Source dataset
uspto-grants-1996_07
Patent number
US05541210

Reaction notes

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