Hydrazine hydrate (1:1) → HCID 15837537, compound

HRID 1736483Notes

Reaction equation

HRID 1736483 reaction equation
O.NN.[Cl:4][C:5]1[CH:6]=[C:7]([CH:11]([N:19]2C(=O)C3=CC=CC=C3C2=O)[CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=2)[CH:8]=[CH:9][CH:10]=1>C(O)C>[Cl:4][C:5]1[CH:6]=[C:7]([CH:11]([NH2:19])[CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=2)[CH:8]=[CH:9][CH:10]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 19973561HCID 19973561, compound

Product 1

HCID 15837537HCID 15837537, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

150 ml of a solution of 5.25 g of hydrazine hydrate in ethanol was added to 12.7 g of the N-{1-(3-chlorophenyl)-2-(pyridin-2-yl)ethyl}phthalimide prepared in the Preparative Example 22. The obtained mixture was heated under reflux for 2 hours. The precipitated crystals were filtered out and the filtrate was concentrated, followed by the addition thereto of ethyl acetate. The precipitated impurities were filtered out and the filtrate was concentrated to give the title compound. Yield: 7.9 g.

Workup

  1. customprepared in the Preparative Example 22
  2. temperatureThe obtained mixture was heated
  3. temperatureunder reflux for 2 hours
  4. filtrationThe precipitated crystals were filtered out
  5. concentrationthe filtrate was concentrated
  6. additionfollowed by the addition
  7. filtrationThe precipitated impurities were filtered out
  8. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-132608d67f314828953036ed19cc4e03
Source dataset
uspto-grants-1996_07
Patent number
US05541213

Reaction notes

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