(4-Phenyl-1H-imidazol-5-yl)methanol → HCID 19973549, compound

HRID 1736484Notes

Reaction equation

HRID 1736484 reaction equation
[C:1]1([C:7]2[N:8]=[CH:9][NH:10][C:11]=2[CH2:12][OH:13])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>[O-2].[O-2].[Mn+4].O1CCOCC1>[C:1]1([C:7]2[N:8]=[CH:9][NH:10][C:11]=2[CH:12]=[O:13])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 1

HCID 20253759(4-Phenyl-1H-imidazol-5-yl)methanol

Product 1

HCID 19973549HCID 19973549, compoundYield 70.8%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 312751,4-DioxaneSolvent

Procedure

1,4-Dioxane (10 ml) was mixed with 1 g of (4-phenyl-1H-imidazol-5-yl)methyl alcohol and 3 g of activated manganese dioxide. The obtained mixture was treated at 80° C. for 30 minutes to conduct a reaction. The reaction mixture was passed through a hot filter and the filter cake was washed with acetone. The washings and the filtrate were combined and concentrated to give 0.7 g of the title compound.

Workup

  1. additionThe obtained mixture was treated at 80° C. for 30 minutes
  2. customa reaction
  3. filtrationa hot filter
  4. washthe filter cake was washed with acetone
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-1d0ccdf2d34941c5830bb3da0c7a2c75
Source dataset
uspto-grants-1996_07
Patent number
US05541213

Reaction notes

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