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HRID1736642

反应详情

EQUATION

反应方程式

HRID 1736642 的结构方程式

REACTANTS

反应物

3
结构：Cl.NO
HCID443297

未命名化合物

结构：COC(=O)[C@H]1CC[C@H]2[C@@H]3CC(=O)[C@@]4(O)C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
HCID15380074

未命名化合物

结构：CC(=O)[O-].O.O.O.[Na+]
HCID23665404

Acetic acid, sodium salt, trihydrate

C2H9NaO5

PRODUCTS

生成物

1
结构：COC(=O)[C@H]1CC[C@H]2[C@@H]3CC(=NO)[C@@]4(O)C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
HCID86749672

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCO
溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

A suspension of 17β-Carbomethoxy-6-oxo-3β,5α-dihydroxy-androstane, 8 g, as prepared in example 17, hydroxylamine hydrochloride (12 g) and sodium acetate trihydrate (16 g) in ethanol (100 mL) is heated at reflux for 1 h. The reaction mixture is cooled to ambient temperature and filtered to afford 17β-carbomethoxy-6-oximino-3β,5α-dihydroxyandrostane as a white solid, mp 234°-237° C. dec. Anal. Calcd. for C21H33NO5.H2O: C, 63.34; H, 8.88; N, 3.53. Found: C, 62.91; H, 8.98; N, 3.27.

WORKUP

后处理

  1. temperatureis heated
  2. temperatureat reflux for 1 h
  3. filtrationfiltered