1-Phenylpiperazine → alpha-{[1-(4-Phenylpiperazinyl)]methyl}benzeneacetic acid

HRID 1736648Notes

Reaction equation

HRID 1736648 reaction equation
[C:1]1([N:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:13]([OH:23])(=[O:22])[C:14]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[CH2:15]>C(O)C>[C:1]1([N:7]2[CH2:12][CH2:11][N:10]([CH2:15][CH:14]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[C:13]([OH:23])=[O:22])[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 70961-PhenylpiperazineHCID 68114Atropic acid

Product 1

HCID 19433570alpha-{[1-(4-Phenylpiperazinyl)]methyl}benzeneacetic acid

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1-Phenylpiperazine and atropic acid in ethanol is heated under reflux for 18 h, cooled to room temperature, and evaporated in vacuo. The solid is triturated with acetone to give the title product.

Workup

  1. temperatureunder reflux for 18 h
  2. customevaporated in vacuo
  3. customThe solid is triturated with acetone

Sources & evidence

ORD record
ord-c01c36e3f54a425eb1d7bffdd9f68b80
Source dataset
uspto-grants-1996_07
Patent number
US05541326

Reaction notes

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