HCID 53953173, compound → HCID 15069314, compound

HRID 1736774Notes

Reaction equation

HRID 1736774 reaction equation
C([O:8][C:9]1[C:17]2[N:16]=[C:15]([CH2:18][CH2:19][CH2:20][CH3:21])[N:14]([CH2:22][C:23]3[CH:28]=[CH:27][C:26]([C:29]4[C:30]([C:35]([OH:37])=[O:36])=[CH:31][CH:32]=[CH:33][CH:34]=4)=[CH:25][CH:24]=3)[C:13]=2[C:12]([CH3:38])=[CH:11][CH:10]=1)C1C=CC=CC=1.[H][H]>CO.CN(C)C=O.[OH-].[OH-].[Pd+2]>[CH2:18]([C:15]1[N:14]([CH2:22][C:23]2[CH:24]=[CH:25][C:26]([C:29]3[C:30]([C:35]([OH:37])=[O:36])=[CH:31][CH:32]=[CH:33][CH:34]=3)=[CH:27][CH:28]=2)[C:13]2[C:12]([CH3:38])=[CH:11][CH:10]=[C:9]([OH:8])[C:17]=2[N:16]=1)[CH2:19][CH2:20][CH3:21]

Participants

5

Reactant 2

HCID 53953173HCID 53953173, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 15069314HCID 15069314, compound

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 21901440N,N-dimethylformamide methanolSolvent

Procedure

Prepared in analogous manner to Example 57 from 4'-[(4-benzyloxy-2-n-butyl-7-methyl-benzimidazol-1-yl)-methyl]biphenyl-2-carboxylic acid and hydrogen in methanol/dimethylformamide in the presence of 20% palladium hydroxide on carbon.

Sources & evidence

ORD record
ord-cb2fbc1891e74df48fa913be9673e1fb
Source dataset
uspto-grants-1996_07
Patent number
US05541229

Reaction notes

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