Trifluoroacetic acid → HCID 15069214, compound

HRID 1736812Notes

Reaction equation

HRID 1736812 reaction equation
[CH2:1]([C:5]1[N:9]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]3[C:18]([C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])=[CH:19][CH:20]=[CH:21][CH:22]=3)=[CH:13][CH:12]=2)[C:8]2[CH:30]=[CH:31][C:32]([S:34]([N:37]([CH3:39])[CH3:38])(=[O:36])=[O:35])=[CH:33][C:7]=2[N+:6]=1[O-])[CH2:2][CH2:3][CH3:4].FC(F)(F)C(O)=O>[Ni].C(Cl)Cl>[CH2:1]([C:5]1[N:9]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]3[C:18]([C:23]([O:25][C:26]([CH3:28])([CH3:29])[CH3:27])=[O:24])=[CH:19][CH:20]=[CH:21][CH:22]=3)=[CH:13][CH:12]=2)[C:8]2[CH:30]=[CH:31][C:32]([S:34]([N:37]([CH3:39])[CH3:38])(=[O:35])=[O:36])=[CH:33][C:7]=2[N:6]=1)[CH2:2][CH2:3][CH3:4]

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 15104392HCID 15104392, compound

Product 1

HCID 15069214HCID 15069214, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 6344DichloromethaneSolvent

Procedure

Prepared in analogous manner to Example 9 from tert.butyl 4'-[(2-n-butyl-5-dimethylaminosulphonyl-3-N-oxido-benzimidazol-1-yl)-methyl]biphenyl-2-carboxylate by catalytic hydrogenation in the presence of Raney nickel and subsequent reaction with trifluoroacetic acid in methylene chloride.

Sources & evidence

ORD record
ord-cedc7276b5be40bca4ab625c7df3d2e7
Source dataset
uspto-grants-1996_07
Patent number
US05541229

Reaction notes

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