Sodium Hydroxide → HCID 19433627, compound

HRID 1737078Notes

Reaction equation

HRID 1737078 reaction equation
C([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([NH:15][C:16]([C:18]1[O:22][C:21]([C:23]([NH:25][C:26]3[CH:27]=[C:28]4[C:32](=[CH:33][CH:34]=3)[NH:31][C:30]([C:35]([O:37]CC)=[O:36])=[CH:29]4)=[O:24])=[CH:20][CH:19]=1)=[O:17])=[CH:10][CH:9]=2)=[O:5])C.[OH-].[Na+]>CO>[O:22]1[C:21]([C:23]([NH:25][C:26]2[CH:27]=[C:28]3[C:32](=[CH:33][CH:34]=2)[NH:31][C:30]([C:35]([OH:37])=[O:36])=[CH:29]3)=[O:24])=[CH:20][CH:19]=[C:18]1[C:16]([NH:15][C:11]1[CH:12]=[C:13]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([C:4]([OH:5])=[O:3])=[CH:14]2)=[O:17]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 70302783HCID 70302783, compound

Product 1

HCID 19433627HCID 19433627, compoundYield 41%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

5,5'-[2,5-furandiylbis(carbonylimino)]bis-1H-indole-2-carboxylic acid diethyl ester (60 mg, 0.11 mM) is suspended in methanol (0.4 mL) and treated with N NaOH (0.25 mL). After 5 days the reaction is evaporated in vacuo and the residue dissovlved in water and the solution acidified to pH 2 with N HCl. This solution is freeze dried leaving 5,5'-[2,5-furandiylbis(carbonylimino)]bis-1H-indole-2-carboxylic acid (22 mg).

Workup

  1. customAfter 5 days the reaction is evaporated in vacuo
  2. customdried

Sources & evidence

ORD record
ord-37317e8f7b274a8f82523f39354974e4
Source dataset
uspto-grants-1996_07
Patent number
US05541339

Reaction notes

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