2-Aminophenol → HCID 10904161, compound

HRID 1737140Notes

Reaction equation

HRID 1737140 reaction equation
[CH2:1]([CH:3]([CH2:18][CH2:19][CH2:20][CH3:21])[CH2:4][N:5]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[N:7]=[C:6]1[C:14](Cl)(Cl)Cl)[CH3:2].[NH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[OH:29].C(N(CC)CC)C>C(O)C>[CH2:1]([CH:3]([CH2:18][CH2:19][CH2:20][CH3:21])[CH2:4][N:5]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[N:7]=[C:6]1[C:14]1[O:29][C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=2[N:22]=1)[CH3:2]

Participants

5

Reactant 3

HCID 58012-AminophenolHCID 8471TriethylamineHCID 9946252HCID 9946252, compound

Product 1

HCID 10904161HCID 10904161, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

28.2 g (0.12 mol) of 1-(2-ethylhexyl)-2-trichloromethylbenzimidazole (prepared by reacting N-2-ethylhexyl-o-phenylenediamine with trichloroacetamido methyl ester), 13.1 g (0.12 mot) of o-aminophenol and 39.4 g (0.38 mot) of triethylamine in 150 ml of ethanol are stirred at room temperature for 15 hours. The ethanol is subsequently removed on a rotary evaporator, ethyl acetate is added to the residue which remains, and the mixture is washed with water and dried over sodium sulfate. 35% of product is identified by BPLC in the product mixture thus ob-5 tained; isolation can be carried out, for example, by column chromatography.

Workup

  1. customThe ethanol is subsequently removed on a rotary evaporator, ethyl acetate
  2. additionis added to the residue which
  3. washthe mixture is washed with water
  4. dry with materialdried over sodium sulfate

Sources & evidence

ORD record
ord-e23f46c42bcb4ac4be3300f036f5768f
Source dataset
uspto-grants-1999_10
Patent number
US05961960

Reaction notes

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