反应详情

To a solution of the above ester (1.0 g, 0.0023 mol) in ethanol (5 ml), 4N sodium hydroxide (0.6 ml) was added and the mixture was stirred at room temperature for 6 h and then left in a freezer overnight. The reaction mixture was allowed to warm up to room temperature and additional 4N sodium hydroxide (0.6 ml) was added. The mixture was stirred at room temperature for 3 h. Water and 4N hydrochloric acid (1.7 ml) were added, and the mixture was extracted with dichloromethane (2×200 ml). The combined organic extracts were dried (MgSO4) and the solvent was evaporated in vacuo. The residue was stripped twice with dichloromethane and dried in vacuo affording 0.5 g (59%) of the title compound as an amorphous solid.

1. waitleft in a freezer overnight
2. temperatureto warm up to room temperature
3. stirringThe mixture was stirred at room temperature for 3 h
4. extractionthe mixture was extracted with dichloromethane (2×200 ml)
5. dry with materialThe combined organic extracts were dried (MgSO4)
6. customthe solvent was evaporated in vacuo
7. customdried in vacuo