Formic Acid → 3-(Formylamino)benzoic acid

HRID 1737276Notes

Reaction equation

HRID 1737276 reaction equation
[C:1](OC(=O)C)(=[O:3])C.C(O)=O.[NH2:11][C:12]1[CH:13]=[C:14]([CH:18]=[CH:19][CH:20]=1)[C:15]([OH:17])=[O:16]>O>[CH:1]([NH:11][C:12]1[CH:13]=[C:14]([CH:18]=[CH:19][CH:20]=1)[C:15]([OH:17])=[O:16])=[O:3]

Participants

5

Reactant 3

HCID 284Formic AcidHCID 74193-Aminobenzoic AcidHCID 7918Acetic Anhydride

Product 1

HCID 152489873-(Formylamino)benzoic acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Acetic anhydride (50 ml) was added to 98% formic acid (85 ml). The mixture was stirred at room temperature for 30 mins, then 3-aminobenzoic acid (10 g, 73 mmol) was added and the mixture was stirred for one hour at room temperature. Water (850 ml) was added and the mixture was stirred overnight at room temperature. The resultant white precipitate was collected (10.66 g, 88%).

Workup

  1. stirringthe mixture was stirred for one hour at room temperature
  2. stirringthe mixture was stirred overnight at room temperature
  3. customThe resultant white precipitate was collected (10.66 g, 88%)

Sources & evidence

ORD record
ord-83b8bf8f24ff42b69a95c042de148cc8
Source dataset
uspto-grants-1999_10
Patent number
US05962451

Reaction notes

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