HCID 54282362, compound → HCID 53898882, compound

HRID 1737283Notes

Reaction equation

HRID 1737283 reaction equation
C([O:3][P:4]([O:40]CC)([CH:6]([P:32]([O:37]CC)([O:34]CC)=[O:33])[CH2:7][CH2:8][C:9]([NH:11][C:12]1[CH:13]=[C:14]([C:19](=[C:22]([C:25]2[CH:30]=[CH:29][C:28]([OH:31])=[CH:27][CH:26]=2)[CH2:23][CH3:24])[CH2:20][CH3:21])[CH:15]=[CH:16][C:17]=1[OH:18])=[O:10])=[O:5])C>C(#N)C>[P:4]([CH:6]([P:32]([OH:34])([OH:37])=[O:33])[CH2:7][CH2:8][C:9]([NH:11][C:12]1[CH:13]=[C:14]([C:19](=[C:22]([C:25]2[CH:26]=[CH:27][C:28]([OH:31])=[CH:29][CH:30]=2)[CH2:23][CH3:24])[CH2:20][CH3:21])[CH:15]=[CH:16][C:17]=1[OH:18])=[O:10])([OH:40])([OH:5])=[O:3]

Participants

3

Reactant 1

HCID 54282362HCID 54282362, compound

Product 1

HCID 53898882HCID 53898882, compoundYield 19%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A crude product was obtained in the same manner as in Example 8 except for using 3-(3-(4,4-bis(diethoxyphosphinoyl)butyrylamino)-4-hydroxyphenyl)-4-(4-hydroxyphenyl)-3-hexene (0.48 g) obtained by the process described in Example 32, and then it was purified by a high-performance reversed phase column chromatography (a 0.1% aqueous trifluoroacetic acid solution:acetonitrile) to obtain 3-(3-(4,4-diphosphonobutyrylamino)-4-hydroxyphenyl)-4-(4-hydroxyphenyl)-3-hexene (74 mg, yield 19%).

Workup

  1. customobtained by the process
  2. customit was purified by

Sources & evidence

ORD record
ord-037a2dc4a4294930b70c13c95a2d7666
Source dataset
uspto-grants-1999_10
Patent number
US05962438

Reaction notes

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