Hydrochloric Acid → HCID 21842261, compound

Participants

Reaction Steps

0.82 g (0.00187 mol) of 3-(5-dibutylaminomethyl-oxazol-2-yl)-8-fluoro-5-methyl-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one in 50 ml of acetic acid was treated with 0.53 ml (0.00196 mol) of 3.7N ethanolic hydrochloric acid. After stirring at 0° for 1/2 hr. the white suspension was suction filtered. There was obtained 0.84 g (94%) of 3-(5-dibutylaminomethyl-oxazol-2-yl)-8-fluoro-5-methyl-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one hydrochloride (1:1) as white crystals; m.p. 251-254° (dec.).

Provenance & Evidence