Hydrochloric Acid → HCID 21842261, compound

HRID 1737333Notes

Reaction equation

HRID 1737333 reaction equation
[CH2:1]([N:5]([CH2:10][C:11]1[O:15][C:14]([C:16]2[N:17]=[CH:18][N:19]3[C:25]4[CH:26]=[CH:27][C:28]([F:30])=[CH:29][C:24]=4[C:23](=[O:31])[N:22]([CH3:32])[CH2:21][C:20]=23)=[N:13][CH:12]=1)[CH2:6][CH2:7][CH2:8][CH3:9])[CH2:2][CH2:3][CH3:4].[ClH:33]>C(O)(=O)C>[ClH:33].[CH2:1]([N:5]([CH2:10][C:11]1[O:15][C:14]([C:16]2[N:17]=[CH:18][N:19]3[C:25]4[CH:26]=[CH:27][C:28]([F:30])=[CH:29][C:24]=4[C:23](=[O:31])[N:22]([CH3:32])[CH2:21][C:20]=23)=[N:13][CH:12]=1)[CH2:6][CH2:7][CH2:8][CH3:9])[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21842235HCID 21842235, compound

Product 1

HCID 21842261HCID 21842261, compoundYield 94.4%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

0.82 g (0.00187 mol) of 3-(5-dibutylaminomethyl-oxazol-2-yl)-8-fluoro-5-methyl-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one in 50 ml of acetic acid was treated with 0.53 ml (0.00196 mol) of 3.7N ethanolic hydrochloric acid. After stirring at 0° for 1/2 hr. the white suspension was suction filtered. There was obtained 0.84 g (94%) of 3-(5-dibutylaminomethyl-oxazol-2-yl)-8-fluoro-5-methyl-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one hydrochloride (1:1) as white crystals; m.p. 251-254° (dec.).

Workup

  1. filtrationfiltered

Sources & evidence

ORD record
ord-54d295716932404cbf76879e369641a8
Source dataset
uspto-grants-1999_10
Patent number
US05962450

Reaction notes

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