Hydrochloric Acid → HCID 21842302, compound

Participants

Reaction Steps

1.1 g (0.00247 mol) of 7-chloro-3-(5-dipropylaminomethyl-oxazol-2-yl)-8-fluoro-5-methyl-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one in 50 ml of ethyl acetate were treated with 0.50 ml (0.00185 mol) of 3.7N ethanolic hydrochloric acid. After stirring at 0° for 1 hr. the white suspension was suction filtered. There was obtained 0.97 g (81%) of 7-chloro-3-(5-dipropylaminomethyl-oxazol-2-yl)-8-fluoro-5-methyl-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one hydrochloride (1:1) as white crystals; m.p. 243-245°.

Provenance & Evidence