Hydrochloric Acid → HCID 21842302, compound

HRID 1737337Notes

Reaction equation

HRID 1737337 reaction equation
[Cl:1][C:2]1[C:7]2[C:8](=[O:30])[N:9]([CH3:29])[CH2:10][C:11]3[N:12]([CH:13]=[N:14][C:15]=3[C:16]3[O:17][C:18]([CH2:21][N:22]([CH2:26][CH2:27][CH3:28])[CH2:23][CH2:24][CH3:25])=[CH:19][N:20]=3)[C:6]=2[CH:5]=[CH:4][C:3]=1[F:31].Cl>C(OCC)(=O)C>[ClH:1].[Cl:1][C:2]1[C:7]2[C:8](=[O:30])[N:9]([CH3:29])[CH2:10][C:11]3[N:12]([CH:13]=[N:14][C:15]=3[C:16]3[O:17][C:18]([CH2:21][N:22]([CH2:26][CH2:27][CH3:28])[CH2:23][CH2:24][CH3:25])=[CH:19][N:20]=3)[C:6]=2[CH:5]=[CH:4][C:3]=1[F:31]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21842230HCID 21842230, compound

Product 1

HCID 21842302HCID 21842302, compoundYield 162.8%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

1.1 g (0.00247 mol) of 7-chloro-3-(5-dipropylaminomethyl-oxazol-2-yl)-8-fluoro-5-methyl-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one in 50 ml of ethyl acetate were treated with 0.50 ml (0.00185 mol) of 3.7N ethanolic hydrochloric acid. After stirring at 0° for 1 hr. the white suspension was suction filtered. There was obtained 0.97 g (81%) of 7-chloro-3-(5-dipropylaminomethyl-oxazol-2-yl)-8-fluoro-5-methyl-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one hydrochloride (1:1) as white crystals; m.p. 243-245°.

Workup

  1. filtrationfiltered

Sources & evidence

ORD record
ord-c0fab363b5b840d1913606a89e2674e5
Source dataset
uspto-grants-1999_10
Patent number
US05962450

Reaction notes

Loading…