Hydrochloric Acid → HCID 70069244, compound

HRID 1737367Notes

Reaction equation

HRID 1737367 reaction equation
[Cl:1][C:2]1[C:7]2[C:8](=[O:30])[N:9]3[CH2:29][CH2:28][CH2:27][C@H:10]3[C:11]3[N:12]([CH:13]=[N:14][C:15]=3[C:16]3[S:17][CH:18]=[C:19]([CH2:21][N:22]4[CH2:26][CH2:25][CH2:24][CH2:23]4)[N:20]=3)[C:6]=2[CH:5]=[CH:4][CH:3]=1.Cl>O>[ClH:1].[Cl:1][C:2]1[C:7]2[C:8](=[O:30])[N:9]3[CH2:29][CH2:28][CH2:27][C@H:10]3[C:11]3[N:12]([CH:13]=[N:14][C:15]=3[C:16]3[S:17][CH:18]=[C:19]([CH2:21][N:22]4[CH2:23][CH2:24][CH2:25][CH2:26]4)[N:20]=3)[C:6]=2[CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 70068062(S)-8-chloro-1-(4-pyrrolidin-1-ylmethyl-thiazol-2-yl)-11,12,13,13a-tetrahydro-9H-imidazo-[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepin-9-one

Product 1

HCID 70069244HCID 70069244, compoundYield 199.4%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

0.56 g (0.0012 mol) (S)-8-chloro-1-(4-pyrrolidin-1-ylmethyl-thiazol-2-yl)-11,12,13,13a-tetrahydro-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepin-9-one was suspended in 10 ml of water and treated with 12 ml of 0.1N (0.0012 mol) aqueous hydrochloric acid. After stirring at room temperature for 1 hr. the mixture was filtered and the filtrate was lyophilized. There was obtained 0.57 g (93%) of (S)-8-chloro-1-(4-pyrrolidin-1-ylmethyl-thiazol-2-yl)-11,12,13,13a-tetrahydro-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepin-9-one hydrochloride (1:1).

Workup

  1. filtrationthe mixture was filtered

Sources & evidence

ORD record
ord-cb766a5270d741ee88b4f8e4e53ffe80
Source dataset
uspto-grants-1999_10
Patent number
US05962450

Reaction notes

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