Hydrochloric Acid → HCID 21842297, compound

HRID 1737385Notes

Reaction equation

HRID 1737385 reaction equation
[CH2:1]([N:4]([CH2:8][C:9]1[N:10]=[C:11]([C:14]2[N:15]=[CH:16][N:17]3[C:23]4[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=4[C:21](=[O:28])[N:20]([CH3:29])[CH2:19][C:18]=23)[O:12][CH:13]=1)[CH2:5][CH2:6][CH3:7])[CH2:2][CH3:3].[ClH:30]>C(O)C>[ClH:30].[CH2:1]([N:4]([CH2:8][C:9]1[N:10]=[C:11]([C:14]2[N:15]=[CH:16][N:17]3[C:23]4[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=4[C:21](=[O:28])[N:20]([CH3:29])[CH2:19][C:18]=23)[O:12][CH:13]=1)[CH2:5][CH2:6][CH3:7])[CH2:2][CH3:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21842262HCID 21842262, compound

Product 1

HCID 21842297HCID 21842297, compoundYield 84%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

0.24 g (0.00061 mol) of 3-(4-dipropylaminomethyl-oxazol-2-yl)-5-methyl-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one was dissolved in 30 ml of ethanol and treated with 0.16 ml (0.00061 mol) of 3.7N ethanolic hydrochloric acid. The solution was completely freed from the solvents and recrystallized from ethanol/diethyl ether. There was obtained 0.22 g (84%) of 3-(4-dipropylaminomethyl-oxazol-2-yl)-5-methyl-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one hydrochloride as white crystals; m.p. 203-205°.

Workup

  1. customrecrystallized from ethanol/diethyl ether

Sources & evidence

ORD record
ord-4fc001c9fb7746f0b0e33408631d8ba6
Source dataset
uspto-grants-1999_10
Patent number
US05962450

Reaction notes

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