Hydrochloric Acid → HCID 21842255, compound

HRID 1737392Notes

Reaction equation

HRID 1737392 reaction equation
[Cl:1][C:2]1[C:7]2[C:8](=[O:30])[N:9]([CH3:29])[CH2:10][C:11]3[N:12]([CH:13]=[N:14][C:15]=3[C:16]3[O:17][CH:18]=[C:19]([CH2:21][N:22]([CH:26]([CH3:28])[CH3:27])[CH:23]([CH3:25])[CH3:24])[N:20]=3)[C:6]=2[CH:5]=[CH:4][CH:3]=1.Cl>C(O)C>[ClH:1].[Cl:1][C:2]1[C:7]2[C:8](=[O:30])[N:9]([CH3:29])[CH2:10][C:11]3[N:12]([CH:13]=[N:14][C:15]=3[C:16]3[O:17][CH:18]=[C:19]([CH2:21][N:22]([CH:26]([CH3:28])[CH3:27])[CH:23]([CH3:24])[CH3:25])[N:20]=3)[C:6]=2[CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21842256HCID 21842256, compound

Product 1

HCID 21842255HCID 21842255, compoundYield 187.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

0.10 g (0.00023 mol) of 7-chloro-3-(4-diisopropylaminomethyl-oxazol-2-yl)-5-methyl-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one was dissolved in 10 ml of ethanol and treated with 0.063 ml (0.00023 mol) of 3.7N ethanolic hydrochloric acid. The solution was completely freed from the solvents and recrystallized from ethanol/diethyl ether. There was obtained 0.10 g (92%) of 7-chloro-3-(4-diisopropylaminomethyl-oxazol-2-yl)-5-methyl-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one hydrochloride as white crystals; m.p. 228-230°.

Workup

  1. customrecrystallized from ethanol/diethyl ether

Sources & evidence

ORD record
ord-6ca4d273d3474dc18f0dd13b05e5d282
Source dataset
uspto-grants-1999_10
Patent number
US05962450

Reaction notes

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