HCID 4189924, compound → HCID 54091467, compound

HRID 1737402Notes

Reaction equation

HRID 1737402 reaction equation
[CH:1]1([N:4]2[C:13]3[C:8](=[C:9]([NH2:17])[C:10]([F:16])=[C:11](F)[C:12]=3[F:14])[C:7](=[O:18])[C:6]([C:19]([OH:21])=[O:20])=[CH:5]2)[CH2:3][CH2:2]1.[CH3:22][O:23][N:24]=[C:25]1[CH:29]([CH2:30][NH2:31])[CH2:28][NH:27][CH2:26]1>>[CH:1]1([N:4]2[C:13]3[C:8](=[C:9]([NH2:17])[C:10]([F:16])=[C:11]([N:27]4[CH2:28][CH:29]([CH2:30][NH2:31])[C:25](=[N:24][O:23][CH3:22])[CH2:26]4)[C:12]=3[F:14])[C:7](=[O:18])[C:6]([C:19]([OH:21])=[O:20])=[CH:5]2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 4189924HCID 4189924, compoundHCID 139109475-Amino-1-cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Product 1

HCID 54091467HCID 54091467, compoundYield 40%

Procedure

143 mg (0.5 mmole) of 1-cyclopropyl-5-amino-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid and 205 mg (0.55 mmole) of 4-aminomethylpyrrolidin-3-one O-methyloxime ditrifluorcacetate were refluxed for 4 hours under heating according to the same manner as Example 177. Then, the reaction solution was concentrated and the residue was purified with preparative HPLC to obtain 84 mg (Yield: 40%) of the title compound.

Workup

  1. temperatureunder heating
  2. concentrationThen, the reaction solution was concentrated
  3. customthe residue was purified with preparative HPLC

Sources & evidence

ORD record
ord-629c7353a4e2429fbb70dcf934784292
Source dataset
uspto-grants-1999_10
Patent number
US05962468

Reaction notes

Loading…