HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 4189924, compound → HCID 54091467, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 4189924 | HCID 4189924 | — |
| Reactant | 5-Amino-1-cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | HCID 13910947 | — |
| Product | HCID 54091467 | HCID 54091467 | 40% |
Reaction Steps
143 mg (0.5 mmole) of 1-cyclopropyl-5-amino-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid and 205 mg (0.55 mmole) of 4-aminomethylpyrrolidin-3-one O-methyloxime ditrifluorcacetate were refluxed for 4 hours under heating according to the same manner as Example 177. Then, the reaction solution was concentrated and the residue was purified with preparative HPLC to obtain 84 mg (Yield: 40%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05962468 |
| Source dataset | uspto-grants-1999_10 |
| ORD ID | ord-629c7353a4e2429fbb70dcf934784292 |
| Source note | uspto-grants-1999_10 |