HRID1737438

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID81531

Diisopropylethylamine

C8H19N

HCID70028544

未命名化合物

结构：CN(C[C@@H](CCBr)c1ccc(Cl)cc1)C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1

HCID86754568

未命名化合物

PRODUCTS

生成物

结构：CN(C[C@@H](CCN1CCC2(CC1)CSc1ccccc12)c1ccc(Cl)cc1)C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1

HCID18392704

未命名化合物

PROCEDURE

实验过程

The title compound was prepared as in Example 21 from 4-bromo-2-(S)-(4-chlorophenyl)-1-(N-(3,5-bistrifluoromethylbenzoyl)-methylamino)butane and spiro(2,3-dihydrobenzothiophene-3,4'-piperidine) hydrochloride except that 3 eq. of diisopropylethylamine were used.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5aeff29a18c8455bb22616d6cc25140c
来源数据集: uspto-grants-1999_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05962462
来源说明: uspto-grants-1999_10

反应 SMILES

Br[CH2:2][CH2:3][C@@H:4]([C:24]1[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][CH:25]=1)[CH2:5][N:6]([CH3:23])[C:7](=[O:22])[C:8]1[CH:13]=[C:12]([C:14]([F:17])([F:16])[F:15])[CH:11]=[C:10]([C:18]([F:21])([F:20])[F:19])[CH:9]=1.Cl.[NH:32]1[CH2:37][CH2:36][C:35]2([C:41]3[CH:42]=[CH:43][CH:44]=[CH:45][C:40]=3[S:39][CH2:38]2)[CH2:34][CH2:33]1.C(N(C(C)C)CC)(C)C>>[Cl:30][C:27]1[CH:26]=[CH:25][C:24]([C@@H:4]([CH2:5][N:6]([CH3:23])[C:7](=[O:22])[C:8]2[CH:9]=[C:10]([C:18]([F:19])([F:20])[F:21])[CH:11]=[C:12]([C:14]([F:16])([F:15])[F:17])[CH:13]=2)[CH2:3][CH2:2][N:32]2[CH2:37][CH2:36][C:35]3([C:41]4[CH:42]=[CH:43][CH:44]=[CH:45][C:40]=4[S:39][CH2:38]3)[CH2:34][CH2:33]2)=[CH:29][CH:28]=1