Hydrochloric Acid → HCID 21912326, compound

HRID 1737692Notes

Reaction equation

[CH2:1]([CH:3]([NH:6][C:7]1[C:12]([N+:13]([O-])=O)=[C:11]([O:16][C:17]2[C:22]([CH3:23])=[CH:21][C:20]([CH3:24])=[CH:19][C:18]=2[CH3:25])[N:10]=[C:9]([CH3:26])[N:8]=1)[CH2:4][CH3:5])[CH3:2].Cl>>[CH2:1]([CH:3]([NH:6][C:7]1[C:12]([NH2:13])=[C:11]([O:16][C:17]2[C:22]([CH3:23])=[CH:21][C:20]([CH3:24])=[CH:19][C:18]=2[CH3:25])[N:10]=[C:9]([CH3:26])[N:8]=1)[CH2:4][CH3:5])[CH3:2]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 21912366HCID 21912366, compound

Product 1

HCID 21912326HCID 21912326, compound

Procedure

The title compound was prepared by hydrogenation of (1-ethyl-propyl)-[2-methyl-5-nitro-6-(2,4,6-trimethyl-phenoxy)-pyrimidin-4-yl]-amine by the method analogous to that described in Example 93. 1H NMR(CDCl3) δ6.88(s,2H), 4.52(d,1H), 4.10(m,1H), 35 2.94(brs,2H), 2.30(s,3H), 2.23(s,3H), 2.09(s,6H), 1.4-1.8(m,4H), 0.95(t,6H) ppm. The corresponding HCl salt, mp 248-250° C. 1H NMR(CD3OD) δ6.91(s,2H), 4.00(m,1H), 2.39(s,3H), 2.28(s,3H), 2.07(s,6H), 1.6-1.8(m,4H), 1.00(t,6H) ppm.

Sources & evidence

ORD record: ord-c4527180daa94d6291baa9cef098b45d
Source dataset: uspto-grants-1999_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05962479

Reaction notes

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