反应详情

1-[1-(4-cyanophenyl)-2-hydroxy4-phenylbutyl]-1,2,4-triazole (0.42 g, 0.00132 mol) is dissolved into acetonitrile. Phosphorous pentachloride (0.27 g, 0.0013 mol) is added into the solution and the mixture is refluxed for 2 hours. Acetonitrile is evaporated, the residue is dissolved with 2 M aqueous sodium hydroxide and extracted with methylene chloride. Methylene chloride is dried and the product is crystallized from ethyl acetate as hydrogen chloride salt (isomer a).

1. temperaturethe mixture is refluxed for 2 hours
2. customAcetonitrile is evaporated
3. dissolutionthe residue is dissolved with 2 M aqueous sodium hydroxide
4. extractionextracted with methylene chloride
5. dry with materialMethylene chloride is dried
6. customthe product is crystallized from ethyl acetate as hydrogen chloride salt (isomer a)