Phosphorus pentachloride → HCID 70276105, compound

Participants

Reaction Steps

1-[1-(4-cyanophenyl)-2-hydroxy4-phenylbutyl]-1,2,4-triazole (0.42 g, 0.00132 mol) is dissolved into acetonitrile. Phosphorous pentachloride (0.27 g, 0.0013 mol) is added into the solution and the mixture is refluxed for 2 hours. Acetonitrile is evaporated, the residue is dissolved with 2 M aqueous sodium hydroxide and extracted with methylene chloride. Methylene chloride is dried and the product is crystallized from ethyl acetate as hydrogen chloride salt (isomer a).

Provenance & Evidence