Trimethylsilyl isocyanate → HCID 54376510, compound

HRID 1737918Notes

Reaction equation

HRID 1737918 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12](=[O:13])[C:11](=[CH:14][C:15]3[C:23]4[C:18](=[CH:19][C:20]([Cl:25])=[CH:21][C:22]=4[Cl:24])[NH:17][C:16]=3[C:26]([OH:28])=[O:27])[CH2:10][N:9]2[C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])=[CH:4][CH:3]=1.C[Si]([N:40]=[C:41]=[O:42])(C)C>O1CCCC1>[C:32]([O:31][C:29]([N:9]1[CH2:10][C:11](=[CH:14][C:15]2[C:23]3[C:18](=[CH:19][C:20]([Cl:25])=[CH:21][C:22]=3[Cl:24])[NH:17][C:16]=2[C:26]([OH:28])=[O:27])[C:12](=[O:13])[N:8]1[C:5]1[CH:6]=[CH:7][C:2]([NH:1][C:41]([NH2:40])=[O:42])=[CH:3][CH:4]=1)=[O:30])([CH3:35])([CH3:34])[CH3:33]

Participants

4

Reactant 2

HCID 70696Trimethylsilyl isocyanateHCID 53927932HCID 53927932, compound

Product 1

HCID 54376510HCID 54376510, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of example 16 (0.070 g) in tetrahydrofuran (4 ml) under nitrogen at room temperature was added trimethylsilylisocyanate (0.080 ml). The solution was refluxed for 4 hrs, after which time the product was seen to precipitate from the solution. The solid was filtered off and washed with tetrahydrofuran (10 ml) affording the title compound as an orange solid. (0.042 g).

Workup

  1. temperatureThe solution was refluxed for 4 hrs
  2. customto precipitate from the solution
  3. filtrationThe solid was filtered off
  4. washwashed with tetrahydrofuran (10 ml)

Sources & evidence

ORD record
ord-a56bf92ad80a426db27ebdb9870c6906
Source dataset
uspto-grants-1999_10
Patent number
US05962496

Reaction notes

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