6,7-Dimethoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-amine → HCID 12381631, compound

HRID 1738161Notes

Reaction equation

HRID 1738161 reaction equation
[CH2:1]([NH:4][CH:5]1[CH2:14][CH2:13][C:12]2[C:7](=[CH:8][C:9]([O:17]C)=[C:10]([O:15]C)[CH:11]=2)[CH2:6]1)[CH2:2][CH3:3]>Br>[CH2:1]([NH:4][CH:5]1[CH2:14][CH2:13][C:12]2[C:7](=[CH:8][C:9]([OH:17])=[C:10]([OH:15])[CH:11]=2)[CH2:6]1)[CH2:2][CH3:3]

Participants

3

Reactant 1

HCID 123816206,7-Dimethoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-amine

Product 1

HCID 12381631HCID 12381631, compound

Reagents, catalysts & solvents 1

HCID 260Hydrogen BromideSolvent

Procedure

2-(N-propyl)amino-6,7 dimethoxy tetraline (prepared as described in Example 2 of the Italian patent 48779 A/86-23/12/1986) (6.6 g; 0.026 moles) were dissolved in 33 ml of 47% HBr and the resulting solution was kept at the reflux temperature overnight. Subsequently the solution was concentrated under vacuum and the residue was repeatedly washed with acetone to eliminate the excess amount of bromide acid. 8 g of a solid residue was obtained that was used as such in the following step.

Workup

  1. customwas kept at the reflux temperature overnight
  2. concentrationSubsequently the solution was concentrated under vacuum
  3. washthe residue was repeatedly washed with acetone

Sources & evidence

ORD record
ord-3bde11262a474e36aa8575b7278e5088
Source dataset
uspto-grants-1999_10
Patent number
US05962525

Reaction notes

Loading…