Carbonate Ion → HCID 21715612, compound

HRID 1738371Notes

Reaction equation

HRID 1738371 reaction equation
[CH3:1][C:2]1[O:3][C:4]([C:7]2[C:12]([F:13])=[CH:11][CH:10]=[CH:9][C:8]=2[OH:14])=[CH:5][N:6]=1.CS([C:19]1[N:24]=[C:23]([O:25][CH3:26])[CH:22]=[C:21]([O:27][CH3:28])[N:20]=1)(=O)=O.C(=O)([O-])[O-]>CN(C=O)C>[CH3:1][C:2]1[O:3][C:4]([C:7]2[C:8]([O:14][C:19]3[N:24]=[C:23]([O:25][CH3:26])[CH:22]=[C:21]([O:27][CH3:28])[N:20]=3)=[CH:9][CH:10]=[CH:11][C:12]=2[F:13])=[CH:5][N:6]=1

Participants

5

Reactant 3

HCID 19660Carbonate IonHCID 8383634,6-Dimethoxy-2-(methylsulfonyl)pyrimidineHCID 21715600HCID 21715600, compound

Product 1

HCID 21715612HCID 21715612, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
50 °C

Procedure

4 ml DMF solution containing 0.12 g 2-(2-methyloxazole-5-yl) -3-fluorophenol, 0.12 g 2-methanesulfonyl-4,6-dimethoxypyrimidine and 0.18 g pottasium carbonate was stirred for 14 hours at 50° C. After completing the reaction, the solution reacted was poured into ice water and then extracted with ethyl acetate. The organic layer obtained was washed with water and then dried by using anhydrous magnesium sulfate. After filtration, the solvent used was removed by distillation under reduced pressure, and the residue obtained was treated with petroleum ether, affording the objective substance in an amount of 0.1 g.

Workup

  1. customthe reaction
  2. customthe solution reacted
  3. extractionextracted with ethyl acetate
  4. customThe organic layer obtained
  5. washwas washed with water
  6. customdried
  7. filtrationAfter filtration
  8. customthe solvent used was removed by distillation under reduced pressure
  9. customthe residue obtained
  10. customaffording the objective substance in an amount of 0.1 g

Sources & evidence

ORD record
ord-8f6008b856164d4eb98a2eedaf49674b
Source dataset
uspto-grants-1999_10
Patent number
US05962685

Reaction notes

Loading…