Methanol → HCID 21715617, compound

HRID 1738372Notes

Reaction equation

HRID 1738372 reaction equation
CO.[CH:3]([C:5]1[CH:21]=[CH:20][CH:19]=[CH:18][C:6]=1[O:7][C:8]1[N:13]=[C:12]([O:14][CH3:15])[CH:11]=[C:10]([O:16][CH3:17])[N:9]=1)=O.C1(C)C=CC(S([CH2:31][N+:32]#[C-])(=O)=O)=CC=1.[C:35](=[O:38])([O-])[O-]>C(OCC)(=O)C>[CH3:17][O:16][C:10]1[CH:11]=[C:12]([O:14][CH3:15])[N:13]=[C:8]([O:7][C:6]2[CH:18]=[CH:19][CH:20]=[CH:21][C:5]=2[C:3]2[O:38][CH:35]=[CH:31][N:32]=2)[N:9]=1

Participants

6

Reactant 4

HCID 887MethanolHCID 19660Carbonate IonHCID 161915Tosylmethyl isocyanideHCID 820623Benzaldehyde, 2-[(4,6-dimethoxy-2-pyrimidinyl)oxy]-

Product 1

HCID 21715617HCID 21715617, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To 10 ml methanol, were added 0.52 g 2-(2-formylphenoxy)-4,6-dimethoxypyrimidine), 0.49 g p-toluenesulfonylmethylisocyanide and 0.69 g pottasium carbonate, and the mixture was subjected to reflux with stirring during 15 min. The solution reacted was added with ice, and solid substance precipitated was filtrated. The solid substance obtained was dissolved in ethyl acetate, and the resulting solution was then dried by using anhydrous magnesium sulfate. Then, the solvent used was removed by distillation under reduced pressure, affording the objective substance in an amount of 0.54 g.

Workup

  1. temperatureto reflux
  2. customThe solution reacted
  3. additionwas added with ice, and solid substance
  4. customprecipitated
  5. filtrationwas filtrated
  6. customThe solid substance obtained
  7. customthe resulting solution was then dried
  8. customThen, the solvent used was removed by distillation under reduced pressure
  9. customaffording the objective substance in an amount of 0.54 g

Sources & evidence

ORD record
ord-5e715565ce10495c822ba35e971c2b16
Source dataset
uspto-grants-1999_10
Patent number
US05962685

Reaction notes

Loading…