Carbonate Ion → HCID 21715611, compound

HRID 1738373Notes

Reaction equation

HRID 1738373 reaction equation
C(=O)([O-])[O-].[CH3:5][O:6][C:7]1[CH:12]=[C:11]([O:13][CH3:14])[N:10]=[C:9]([O:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([OH:22])[C:17]=2[C:23]2[O:27][CH:26]=[N:25][CH:24]=2)[N:8]=1.Cl[N:29]1[N:34]=[C:33]([O:35][CH3:36])[CH:32]=[C:31]([O:37][CH3:38])[NH:30]1>CN(C=O)C>[CH3:14][O:13][C:11]1[CH:12]=[C:7]([O:6][CH3:5])[N:8]=[C:9]([O:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([O:22][N:29]3[N:30]=[C:31]([O:37][CH3:38])[CH:32]=[C:33]([O:35][CH3:36])[NH:34]3)[C:17]=2[C:23]2[O:27][CH:26]=[N:25][CH:24]=2)[N:10]=1

Participants

5

Reactant 3

HCID 19660Carbonate IonHCID 21715621HCID 21715621, compoundHCID 221477162-Chloro-4,6-dimethoxy-triazine

Product 1

HCID 21715611HCID 21715611, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent2×

Procedure

To DMF solution containing 0.14 g pottasium carbonate and 0.15 g 5-[2-(4,6-dimethoxypyrimidine-2-yloxy)-6-hydroxyphenyl]oxazole, was added at once DMF solution containing 0.13 g 2-chloro-4,6-dimethoxytriazine. The solution reacted was stirred for a night at room temperature. After completing the reaction, the solution reacted was poured into ice water and then extracted with ethyl acetate. The organic layer obtained was washed with water and saturated saline solution in turn and was then dried by using anhydrous magnesium sulfate. The solvent used was removed by distillation under reduced pressure, affording the objective substance in an amount of 0.22 g.

Workup

  1. customThe solution reacted
  2. customthe reaction
  3. customthe solution reacted
  4. extractionextracted with ethyl acetate
  5. customThe organic layer obtained
  6. washwas washed with water and saturated saline solution in turn
  7. customwas then dried
  8. customThe solvent used was removed by distillation under reduced pressure
  9. customaffording the objective substance in an amount of 0.22 g

Sources & evidence

ORD record
ord-c5759f981aef470f8501f4f4995bddcd
Source dataset
uspto-grants-1999_10
Patent number
US05962685

Reaction notes

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