Dimethylformamide → HCID 22998390, compound

HRID 1738431Notes

Reaction equation

CN(C=O)C.[S:6]([Cl:10])(Cl)(=[O:8])=[O:7].[CH:11]([C:14]1[S:18][C:17]2[CH:19]=[CH:20][CH:21]=[CH:22][C:16]=2[CH:15]=1)([CH3:13])[CH3:12]>>[CH:11]([C:14]1[S:18][C:17]2[CH:19]=[CH:20][CH:21]=[CH:22][C:16]=2[C:15]=1[S:6]([Cl:10])(=[O:8])=[O:7])([CH3:13])[CH3:12]

Participants

Reactant 3

HCID 6228Dimethylformamide

HCID 24648Sulfuryl chloride

HCID 2705232-(Propan-2-yl)-1-benzothiophene

Product 1

HCID 22998390HCID 22998390, compound

Procedure

2-i-propylbenzo[b]thiophene-3-sulfonyl chloride compound was prepared by the method of Example 40B with DMF (5.2 mmoles, 0.40 ml), using sulfuryl chloride (4.2 mmoles, 0.34 ml) and 2-i-propylbenzo[b]thiophene (2.1 mmoles, 0.37 g). Flash chromatography (1% ethyl acetate/hexanes) provided 0.17 g (29%) of a yellow solid.

Sources & evidence

ORD record: ord-589371d07fd34f749e48bbc64a4fc547
Source dataset: uspto-grants-1999_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05962490

Reaction notes

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