Dimethylformamide → HCID 22998421, compound

HRID 1738478Notes

Reaction equation

HRID 1738478 reaction equation
CN(C)C=O.[S:6]([Cl:10])(Cl)(=[O:8])=[O:7].[CH3:11][O:12][C:13]1[CH:14]=[C:15]([CH:26]=[C:27]([O:31][CH3:32])[C:28]=1[O:29][CH3:30])[CH2:16][C:17]1[S:21][C:20]2[CH:22]=[CH:23][CH:24]=[CH:25][C:19]=2[CH:18]=1>>[CH3:11][O:12][C:13]1[CH:14]=[C:15]([CH:26]=[C:27]([O:31][CH3:32])[C:28]=1[O:29][CH3:30])[CH2:16][C:17]1[S:21][C:20]2[CH:22]=[CH:23][CH:24]=[CH:25][C:19]=2[C:18]=1[S:6]([Cl:10])(=[O:8])=[O:7]

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 24648Sulfuryl chlorideHCID 22998434HCID 22998434, compound

Product 1

HCID 22998421HCID 22998421, compound

Procedure

2-(3,4,5-trimethoxybenzyl)-benzo[b]thiophene-3-sulfonylchloride was prepared in the same manner as described in Example 40B. Reaction of dimethylformamide (DMF; 4.8 mmoles, 0.40 mls), sulfuryl chloride (4.1 mmoles, 0.33 mls) and 2-(3,4,5-trimethoxybenzyl)-benzo[b]thiophene (2.4 mmoles, 0.75 g) yielded, after flash chromatography using 20% ethyl acetate/hexanes, 0.29 g (30%) of a yellow-orange oil.

Workup

  1. customyielded

Sources & evidence

ORD record
ord-fd82cca86c314296866175c78c094e5b
Source dataset
uspto-grants-1999_10
Patent number
US05962490

Reaction notes

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