Benzo(B)Thiophene → MLS002608206

HRID 1738492Notes

Reaction equation

HRID 1738492 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]2[CH:6]=[CH:7][CH:8]=[CH:9][C:2]1=2.[Li]C(C)(C)C.[CH3:15][N:16]([CH3:25])[C:17]1[CH:24]=[CH:23][C:20]([CH:21]=[O:22])=[CH:19][CH:18]=1>C1COCC1>[S:1]1[C:5]([CH:21]([OH:22])[C:20]2[CH:19]=[CH:18][C:17]([N:16]([CH3:15])[CH3:25])=[CH:24][CH:23]=2)=[CH:4][C:3]2[CH:6]=[CH:7][CH:8]=[CH:9][C:2]1=2

Participants

5

Reactant 3

HCID 7221Benzo(B)ThiopheneHCID 74794-(Dimethylamino)BenzaldehydeHCID 178418306HCID 178418306, compound

Product 1

HCID 237069MLS002608206

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

α-(2-benzo[b]thienyl)-4-dimethylaminobenzyl alcohol was prepared by the method of Example 40A with benzo[b]thiophene (7.5 mmoles, 1.0 g), t-BuLi (1.7 M, 8.9 mmoles, 5.3 ml), 4-dimethylaminobenzaldehyde (8.9 mmoles, 1.3 g) and THF (20 ml). The crude product (2.4 g) was carried forward without further purification.

Workup

  1. customThe crude product (2.4 g) was carried forward without further purification

Sources & evidence

ORD record
ord-c42e0f6a3b554786b0061461cc849545
Source dataset
uspto-grants-1999_10
Patent number
US05962490

Reaction notes

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