Water → HCID 12159128, compound

HRID 1738727Notes

Reaction equation

HRID 1738727 reaction equation
[NH2:1][CH:2]([CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[CH:3]=[CH2:4].[C:12](=[O:15])([O-])[O-].[Na+].[Na+].[OH2:18]>O1CCCC1>[C:12]1(=[O:15])[N:1]([CH:2]([CH2:5][C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=2)[CH:3]=[CH2:4])[C:5](=[O:18])[C:6]2=[CH:11][CH:10]=[CH:9][CH:8]=[C:7]12

Participants

5

Reactant 3

HCID 962WaterHCID 10340Sodium CarbonateHCID 19973227HCID 19973227, compound

Product 1

HCID 12159128HCID 12159128, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

(RS)-3-Amino-4-phenyl-1-butene (1.2 g, 8.0 mmol) was dissolved in tetrahydrofuran (20 ml). To the solution, a solution of N-carbethoxyphthalimido (2.2 g, 10.0 mmol) in water (20 ml) and anhydrous sodium carbonate (1.06 g, 10.0 mmol) was added and stirred at room temperature for 1 hour. The reaction mixture was concentrated under reduced pressure to remove tetrahydrofuran, followed by extraction with ethyl acetate.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customto remove tetrahydrofuran
  3. extractionfollowed by extraction with ethyl acetate

Sources & evidence

ORD record
ord-520e45918a754eae86fd091f5a9f427e
Source dataset
uspto-grants-1999_10
Patent number
US05962692

Reaction notes

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