Indan-5-amine → HCID 21839589, compound

HRID 1738823Notes

Reaction equation

HRID 1738823 reaction equation
[Cl:1][C:2]1[CH:11]=[N:10][C:5]2[N:6]=[CH:7][N:8]=[CH:9][C:4]=2[CH:3]=1.[NH2:12][C:13]1[CH:14]=[C:15]2[C:19](=[CH:20][CH:21]=1)[CH2:18][CH2:17][CH2:16]2>C(O)(C)C>[ClH:1].[CH2:18]1[C:19]2[C:15](=[CH:14][C:13]([NH:12][C:9]3[C:4]4[CH:3]=[CH:2][CH:11]=[N:10][C:5]=4[N:6]=[CH:7][N:8]=3)=[CH:21][CH:20]=2)[CH2:16][CH2:17]1

Participants

4

Reactant 2

HCID 90496Indan-5-amineHCID 21839560HCID 21839560, compound

Product 1

HCID 21839589HCID 21839589, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

A solution of 6-chloropyrido[2,3-d]pyrimidine (1.656 g, 10 mM) and 5-aminoindan (1.332 g, 10 mM) in isopropanol (60 ml) is heated to reflux for about 20 h. The resulting salt suspension is then cooled to room temperature, filtered and the residue washed with ice-cooled isopropanol to give almost pure title compound in about 80% yield.

Workup

  1. temperatureto reflux for about 20 h
  2. filtrationfiltered
  3. washthe residue washed with ice-
  4. temperaturecooled isopropanol

Sources & evidence

ORD record
ord-7ef7fa26dbc04a01af864f3ba3e86eb2
Source dataset
uspto-grants-1999_10
Patent number
US05965563

Reaction notes

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