Potassium Carbonate → HCID 21839590, compound

HRID 1738824Notes

Reaction equation

HRID 1738824 reaction equation
Cl.[CH2:2]1[C:10]2[C:5](=[CH:6][C:7]([NH:11][C:12]3[C:13]4[CH:21]=[CH:20][CH:19]=[N:18][C:14]=4[N:15]=[CH:16][N:17]=3)=[CH:8][CH:9]=2)[CH2:4][CH2:3]1.C(=O)([O-])[O-].[K+].[K+]>CO>[CH2:2]1[C:10]2[C:5](=[CH:6][C:7]([NH:11][C:12]3[C:13]4[CH:21]=[CH:20][CH:19]=[N:18][C:14]=4[N:15]=[CH:16][N:17]=3)=[CH:8][CH:9]=2)[CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 21839589HCID 21839589, compound

Product 1

HCID 21839590HCID 21839590, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A suspension of 4-(5-indanylamino)-pyrido[2,3-d]pyrimidine hydrochloride (2.988 g, 10 mM) and potassium carbonate (2.764 g, 20 mM) in methanol (60 ml) is stirred at ambient temperature for 0.5 h. The mixture is filtered and the filtrate evaporated under vacuum. The residue is purified by column chromatography using a 93:7 mixture of dichloromethane/methanol as eluant to give pure title compound in 90% yield.

Workup

  1. filtrationThe mixture is filtered
  2. customthe filtrate evaporated under vacuum
  3. customThe residue is purified by column chromatography
  4. additiona 93:7 mixture of dichloromethane/methanol as eluant

Sources & evidence

ORD record
ord-ddafa3047d974b729a7a24841a547b50
Source dataset
uspto-grants-1999_10
Patent number
US05965563

Reaction notes

Loading…