5-Indanol → HCID 21839567, compound

HRID 1738825Notes

Reaction equation

HRID 1738825 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[CH2:7][CH2:6][CH2:5]2.Cl[C:12]1[CH:21]=[N:20][C:15]2[N:16]=[CH:17][N:18]=[CH:19][C:14]=2[CH:13]=1>[OH-].[K+]>[CH2:7]1[C:8]2[C:4](=[CH:3][C:2]([O:1][C:19]3[C:14]4[CH:13]=[CH:12][CH:21]=[N:20][C:15]=4[N:16]=[CH:17][N:18]=3)=[CH:10][CH:9]=2)[CH2:5][CH2:6]1

Participants

4

Reactant 2

HCID 151185-IndanolHCID 21839560HCID 21839560, compound2×

Product 1

HCID 21839567HCID 21839567, compoundYield 60%

Reagents, catalysts & solvents 1

HCID 14797Potassium HydroxideSolvent2×

Procedure

To a solution of 5-hydroxyindan (1.342 g, 10 mM) in 80 ml of aqueous potassium hydroxide solution containing 1.683 g (30 mM) of solid potassium hydroxide is added 6-chloro-pyrido[2,3-d] pyrimidine (1.656 g, 10 mM). The reaction mixture is stirred for about 0.5 h at room temperature until most of the 6-chloro-pyrido[2,3-d]pyrimidine dissolves and then heated on the steam bath for further 0.5 h. The mixture is cooled, filtered and the residue recrystallized from hot aqueous ethanol to give pure title compound in 60% yield.

Workup

  1. dissolutiondissolves
  2. temperatureheated on the steam bath for further 0.5 h
  3. temperatureThe mixture is cooled
  4. filtrationfiltered
  5. customthe residue recrystallized from hot aqueous ethanol

Sources & evidence

ORD record
ord-8e2b102d338047198c7238e242edb212
Source dataset
uspto-grants-1999_10
Patent number
US05965563

Reaction notes

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