5-Indanol → HCID 21839567, compound

Participants

Reaction Steps

To a solution of 5-hydroxyindan (1.342 g, 10 mM) in 80 ml of aqueous potassium hydroxide solution containing 1.683 g (30 mM) of solid potassium hydroxide is added 6-chloro-pyrido[2,3-d] pyrimidine (1.656 g, 10 mM). The reaction mixture is stirred for about 0.5 h at room temperature until most of the 6-chloro-pyrido[2,3-d]pyrimidine dissolves and then heated on the steam bath for further 0.5 h. The mixture is cooled, filtered and the residue recrystallized from hot aqueous ethanol to give pure title compound in 60% yield.

Provenance & Evidence